female mice experiment

COMMENTS

1. Why we need female mice in neuroscience research

   As neuroscientists strive to better understand the human brain, they routinely turn to the mouse, which Datta considers “the flagship vertebrate model for understanding how the brain works.” This is because mouse and human brains share a considerable amount of structural organization and genetic information, so …

2. The Case for Female Mice in Neuroscience Research

   The researchers studied genetically identical males and females from a common strain of lab mouse in a circular open field — a standard lab setup for behavioral neuroscience experiments. In practice, the test involved …

3. Why we need female mice in drug trials

   Female mice are generally tested at each of the four stages of oestrus to generate reliable data. There is also concern that the use of males and females in a same study could reduce statistical power because of a …

4. The influence of sex difference on behavior and adult hippocampal ...

   This study sets out to evaluate whether a sex difference does exist in mouse behavior, and whether female mice featured higher variability.

5. Female mice behave well

   To examine this question, Levy et al. used Mo-Seq, a machine learning algorithm that enables unbiased, high-dimensional analysis of mouse behavior, to profile adult C57BL/6J …

6. Female mice liberated for inclusion in neuroscience and ...

   The underrepresentation of female mice in neuroscience and biomedical research is based on the assumption that females are intrinsically more variable than males and must be tested at …

7. Female mice exhibit less overall variance, with a higher proportion …

   Female mice show less unstructured variance than do male mice, and for both sexes, time of day is the biggest influence on structured variance, with estrous cycle variance …

8. The Case for Female Mice in Neuroscience Research

   Researchers now argue that despite hormone cycles, female mice show more stable exploratory behaviors than males. The findings make a strong case for increasing the inclusion of female mice in neuroscience research.

9. Experimenters’ sex modulates mouse behaviors and neural

   We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its …